Roy and Jessie are a couple in a rocky relationship. Following a stay in Beijing they decide to give their relationship one last go and have another adventure together. They decide to travel on the Transsiberian from China to Moscow. The couple discover that the days of the train's glorious luxury has faded and has been replaced with cold steel carriages and indifferent fellow passengers. It is reputed to include drug traffickers. In the company of a fellow western couple, Carlos and Abby, everything goes well until the four decide to get off the train at one stop. They soon discover that Carlos is a drug dealer who was being pursued by corrupt police officers, and they are now after Jessie. Unwittingly, Roy and Jessie get caught up in the dark world of smuggling and betrayal. And they know that while the train is in motion, there is no means of escape.