Set in a beautiful but economically devastated Pennsylvania steel town, American Rust is a novel of the lost American dream and the desperation—as well as the acts of friendship, loyalty, and love—that arise from its loss. Left alone to care for his aging father after his mother commits suicide and his sister escapes to Yale, Isaac English longs for a life beyond his hometown. But when he finally sets out to leave for good, accompanied by his temperamental best friend, former high school football star Billy Poe, they are caught up in a terrible act of violence that changes their lives forever.