Preface -- Part one: From Bensonhurst to Washington. Brooklyn boy -- Becoming Dr. Fauci -- Heading south -- Part two: The AIDS era. Game changer -- Up close and painful -- The Human Immunodeficiency Virus -- Taking the reins -- Two Brooklyn boys -- Building an AIDS research program -- AIDS strikes close to home -- A global catastrophe -- AIDS activism -- A president, a gentleman, and a friend -- La famiglia -- The changing of the guard -- The search for an HIV vaccine -- The Lazarus effect -- HIV denialism -- An unequal world -- Part three: The wars on terror and disease. Widening the battle -- The day the world changed -- Anthrax -- Going global with AIDS relief -- Smallpox and stockpiles -- Project BioShield -- You have to love Yogi -- A reluctant Congress -- Iraq -- Influenza meets the supply chain -- Legacies -- Part four: Expecting the unexpected. Enter Obama -- Moving toward an HIV-free world -- Epidemics of disease and fear -- Patient X -- Zika and other surprises -- Passing the baton -- Part five: COVID. A disease like none other -- He loves me, he loves me not -- Illegitimi non carborundum -- Epilogue.