Murphy Shepherd, devastated by the loss of his mentor Bones, is thrust back into the fight against human trafficking when the vice president's three daughters are kidnapped. Despite the best security, the daughters are taken without a trace, leaving behind only a dead Secret Service team. Murph and his team are the only ones who can hope to rescue them. As Murph continues the work Bones started, he uncovers a dark network where power and evil rule, and a new presidential candidate emerges with dangerous ties. Murph's journey takes him across the globe, determined to save the missing and dismantle the trafficking network while honoring Bones' legacy of saving the lost.